Menstrual issues

A recent strong increase in heavy menstrual bleeding, was mentioned in the British Medical Journal (BMJ). It is unclear if EMA has looked into this based on their data, what happens when we do it?

select
  reaction,
  count(distinct local_number)
from import.product_reaction 
where reaction ilike '%menstru%' 
group by reaction 
order by count(distinct local_number) desc limit 10;

We can see that related to products, there are 1920 reports mentioning Heavy menstrual bleeding as (one of the) reaction(s).

reactioncount
Heavy menstrual bleeding1920
Intermenstrual bleeding1100
Menstrual disorder1043
Menstruation irregular957
Menstruation delayed819
Premenstrual syndrome91
Premenstrual pain18
Menstrual discomfort17
Menstruation normal10
Menstrual cycle management6
select
 reaction,
 count(distinct local_number)
from import.substance_reaction 
where reaction ilike '%menstru%' 
group by reaction 
order by count(distinct local_number) desc limit 10;
reactioncount
Heavy menstrual bleeding48794
Menstrual disorder30349
Intermenstrual bleeding26426
Menstruation irregular25405
Menstruation delayed18877
Premenstrual syndrome2325
Menstrual discomfort1336
Premenstrual pain921
Menstrual cycle management300
Menstruation normal294

For substances it is 48794reports.

We want to see if any substances stick out.

select a.name, b.* from 
(select
   --reaction,
   substance_id,
   count(distinct local_number) count
 from import.substance_reaction 
 where reaction = 'Heavy menstrual bleeding'
 group by substance_id, reaction) b
 JOIN import.substances a on a.substance_id = b.substance_id
 order by b.count desc limit 10;
namesubstance_idcount
COVID-19 MRNA VACCINE PFIZER-BIONTECH (TOZINAMERAN)4232570025570
COVID-19 MRNA VACCINE MODERNA (ELASOMERAN)409833127791
COVID-19 VACCINE ASTRAZENECA (CHADOX1 NCOV-19)409954395062
LEVONORGESTREL199803405
ETONOGESTREL188321634
DESOGESTREL18500383
ETHINYLESTRADIOL, ETONOGESTREL39209347
LACTOSE25479288
DROSPIRENONE, ETHINYLESTRADIOL59494242
COVID-19 MRNA VACCINE PFIZER-BIONTECH ORIGINAL/OMICRON BA.1 (TOZINAMERAN, RILTOZINAMERAN)60123556212

It seems that, given that "Heavy menstrual bleeding" totals 48794 reports for the substance table and 38423 reports from that same table are related to COVID-19 vaccines, we feel that this should be something of concern. This appears to be something that justifies further research, also by EMA.